Transcribing “silent” DNA resilences it
نویسندگان
چکیده
منابع مشابه
Transcribing “silent” DNA resilences it
Transcribing " silent " DNA resilences it T ranscription of hete-rochromatin during S phase is the key to the faithful inheritance of silenced DNA at the cen-tromere, according to and colleagues. Histone methylation keeps heterochromatin condensed and the genes within silent. Yet the same methylation patterns are passed on to daughter cells. This inheritence requires RNA interference—and thus t...
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The sequence of silent DNA in the human genome (intergenic spacers, introns and synonymous codon positions of protein-coding genes) was found here to have the higher thermostability of corresponding RNA/RNA and RNA/DNA duplexes as compared with randomized sequence. This difference increased with elevation of GC content. The revealed effect was not due to correlation of RNA/RNA and RNA/DNA therm...
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Patterns of codon usage and “silent” DNA divergence suggest that natural selection discriminates among synonymous codons in Drosophila. “Preferred” codons are consistently found in higher frequencies within their synonymous families in Drosophila melanogaster genes. This suggests a simple model of silent DNA evolution where natural selection favors mutations from unpreferred to preferred codons...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1812rr5